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Klinefelter syndrome severity

Klinefelter Syndrome: Causes, Symptoms, Testing & Treatmen

  1. Klinefelter syndrome can vary widely in severity. People with a mild case may not even know they have Klinefelter syndrome. Some men with mild cases only discover that they have Klinefelter syndrome during infertility testing. The use of genetic testing before birth is increasingly being used and sometimes can diagnose Klinefelter syndrome
  2. The number and severity of symptoms vary widely. The most common reason for suspecting that a boy may have Klinefelter syndrome is when a doctor notices that in late puberty, the testicles are much smaller than what is normal. Boys may have undescended testicles, and the penis may be smaller than average
  3. Individuals with Klinefelter syndrome tend to have anxiety, depression, impaired social skills, behavioral problems such as emotional immaturity and impulsivity, attention-deficit/hyperactivity disorder (ADHD), and limited problem-solving skills (executive functioning)
  4. Association between the degree of mosaicism and the severity of syndrome in Turner mosaics and Klinefelter mosaics. Sarkar R, Marimuthu KM. This study, based on the investigations carried on 82 cases of Turners of which 50 of them were mosaics and 85 cases of Klinefelters of which 70 of them were mosaics, is an attempt to explain the vast range.
  5. The severity of Klinefelter Syndrome increases with the number of extra X chromosomes i.e., 48XXXY syndrome or 49XXXXY syndrome. More than half of Klinefelter syndrome embryos eventually undergo a miscarriage and never get born
  6. Infertility and gynecomastia (enlarged breast tissue) are the two most common complaints leading to diagnosis. Other complaints include fatigue, weakness, erectile dysfunction, language impairment, academic problems, subnormal libido, poor self-esteem, osteoporosis and behavior problems. Testing for Klinefelter's syndrome may include
  7. The signs and symptoms of this syndrome vary in severity and occurrence across a spectrum, and therefore the research indicates that up to 75% of affected men and boys are never diagnosed. The NIH further states that, Klinefelter syndrome (47,XXY or KS), is a chromosomal condition which results from the presence of an extra X.

The signs and symptoms of Klinefelter syndrome vary from person to person. The severity of symptoms depends on how many X chromosomes are present. Individuals with more X chromosomes tend to experience more symptoms Not to be confused with XYY syndrome. Klinefelter syndrome (KS), also known as 47,XXY is a syndrome where a male has an additional copy of the X chromosome. The primary features are infertility and small, poorly functioning testicles. Often, symptoms are subtle and subjects do not realize they are affected

Objective: To determine whether men with Klinefelter syndrome (KS) have the same phenotype as men with mosaic KS. Design: Subject identification via prospectively collected database. Setting: Male infertility specialty clinic The most common signs of Klinefelter syndrome involve sexual development and fertility, though for individual men, the severity of symptoms can vary widely. The incidence of Klinefelter syndrome is thought to be increasing. 2  The Genetics of Klinefelter's Syndrome Klinefelter syndrome may affect up to 1 in 500 male births in the world today. 2. A recent Danish study indicated that Klinfelter syndrome was present in 153 per 100,000 babies tested. 3. An estimated 53-55% of conceptions affected with Klinefelter syndrome are expected to survive to term. 4 severity increases as well. As a result, cogni-tive and gonadal development is impaired, (Klinefelter syndrome) and 47,XYY: estimated rates of and indication for post The Klinefelter Syndrome Multi-Specialty clinics are one of the first in the country to address the needs of patients diagnosed with Klinefelter (XXY) Syndrome. What are the signs and symptoms? These can be very mild and so it is estimated only 1 in 4 (25%) of children or adults with KS are ever diagnosed

Klinefelter Syndrome Pediatric Endocrine Societ

Klinefelter syndrome (sometimes called Klinefelter's, KS or XXY) is where boys and men are born with an extra X chromosome. The exact cause is not known but KS is not inherited / hereditary. These symptoms are not present in all patients and can vary in severity It was observed that the severity of the syndrome in Turner mosaics and Klinefelter mosaics increased with the relative increase in the abnormal cell line population It is important to recognise that Klinefelter Syndrome is a spectrum condition; not all patients experience the same symptoms and the level of severity varies significantly. Throughout this site you will find out more about Klinefelter Syndrome and some of the characteristics may seem familiar and relatable to your experience of the condition

Men with Klinefelter may have: An extra X chromosome in every cell, which is the most common An extra X chromosome in only some cells, called mosaic Klinefelter, in which you don't have as many.. Physical manifestations of Klinefelter syndrome are relatively moderate compared with autosomal trisomies (e.g., Down syndrome) because when additional X chromosomes are present, one is.. Klinefelter syndrome (KS) or 47,XXY occurs in 1 in 650 males. Individuals with KS often present with physical characteristics including tall stature, hypogonadism, and fertility problems. In addition to medical findings, the presence of the extra X chromosome can lead to characteristic cognitive and language deficits of varying severity

Klinefelter syndrome: MedlinePlus Genetic

For patients diagnosed with KS, a range of management strategies can be used to improve health outcomes and quality of life. Klinefelter syndrome (KS) is a common genetic condition, affecting one in 450 men. 1 KS is caused by the presence, in men, of one or more supernumerary X chromosomes Klinefelter syndrome is the most common sex chromosome disorder, occurring in about 1/500 live male births. The extra X chromosomes are maternally derived in 60% of cases. Germ cells do not survive in the testes, leading to decreased sperm and androgens. Affected boys tend to be tall with disproportionately long arms and legs

Association between the degree of mosaicism and the

Some cases also report more than two X chromosomes and this increases the severity of symptoms, though cases of more than two X chromosomes are not common. The condition cannot be attributed to any cause (Center for Genetics Education, 2013). Symptoms and signs. Klinefelter syndrome has many symptoms that co-occur, but whose significance may. Klinefelter syndrome is characterized by hypogonadism (micro-orchidism [small testes], oligospermia/azoospermia), gynecomastia in late puberty, hyalinization and fibrosis of the seminiferous.. The association between Klinefelter syndrome and breast cancer is based on both cytogenetic analyses in men who had acquired breast cancer [ 11] and epidemiological studies. It has been calculated that men with Klinefelter syndrome have a 15- to 20-fold higher risk to acquire breast cancer [ 7 , 12] The number and severity of symptoms vary widely. The most common reason for suspecting that a boy may have Klinefelter syndrome is when a doctor notices that in late puberty, the testicles are much smaller than what is normal. Boys may have undescended testicles, and the penis may be smaller than average. Most boys with Klinefelter syndrome

Klinefelter Syndrome Latest Facts: Symptoms, Diagnosis and

  1. If the disease develops, medications can help limit its severity. Endodontic treatment in three taurodontic teeth associated with 48,XXXY Klinefelter syndrome: A review and case report. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, 105(5), 670-677
  2. Klinefelter syndrome is a sex chromosome disorder in boys and men that results from the presence of an extra X chromosome in cells. People typically have 46 chromosomes in each cell, two of which are the sex chromosomes. Females have two X chromosomes (46,XX), and males have one X and one Y chromosome (46,XY). Most often, boys and men with Klinefelter syndrome have the usual X and Y.
  3. The number and severity of symptoms vary widely. The most common reason for suspecting that a boy may have Klinefelter syndrome is when a doctor notices that in late puberty, the testicles are much smaller than what is normal. Boys may have undescended testicles, and the penis may be smaller than average. Most boys with Klinefelter syndrome are.
  4. Klinefelter Syndrome Carla Fedor, RN ----- Introduction . In 1942, Dr. Harry Klinefelter and his coworkers first described the combination of features that has come to be recognized as Klinefelter Syndrome. By the late 1950's, researchers discovered that men with this group o
  5. Klinefelter's Syndrome (KS) is a spectrum condition - the severity and number of symptoms varies considerably from person to person. The following symptoms may occu
  6. Klinefelter syndrome (KS) is a common male chromosomal dis-order (47, XXY) that has been a topic of intrigue and inquiry since the guided by the extent and severity of clinical features as well as in the sense that visuoperceptual and nonverbal skills appear to b

The well-established Klinefelter's Syndrome Association charity was and still is a major lifeline and source of support for patients, particularly the newly diagnosed, their partners and the parents of children and young people with KS. Not all patients experience the same symptoms, and the level of severity varies The Lived Experience of Klinefelter Syndrome: A Narrative Review of the Literature. Download. Related Papers. Socio-emotional problems in boys with sex chromosome aneuploidies compared to a clinical sample. By Bente Haugland. Management of Klinefelter syndrome during transition cism is a common phenomenon in Turner syndrome (TS; 45,X) (Gravholt, Juul, Naeraa, & Hansen, 1996) and mosaic karyotype in these women are associated with a milder phenotype with reduced severity of congenital heart diseases and enhanced fertility compared to nonmosaic TS women (Bernard et al., 2016; Cameron-Pimblett, La What is KS? The term Klinefelter (pronounced KLAHYN-fel-ter) syndrome, or KS, describes a set of features that can occur in a male who is born with an extra X chromosome (pronounced KROH-muh-sohm) in his cells.It is named after Dr. Henry Klinefelter, who identified the condition in the 1940s. 1 Usually, every cell in a male's body, except sperm and red blood cells, contains 46 chromosomes Introduction. Klinefelter syndrome (KS) is a common male chromosomal disorder (47, XXY) that has been a topic of intrigue and inquiry since the 1940s, when it was first described 1.It is a subject of interest because of its wide spectrum of clinical manifestations, which include certain physical features, cognitive delays, and azoospermia

Klinefelter syndrome (KS) is the most prevalent sex chromosome disorder in man and is a common cause of hypogonadism. To describe mortality in KS, we conducted an epidemiological study, using Danish registers covering the entire nation. Association between the degree of mosaicism and the severity of syndrome in Turner mosaics and. Klinefelter syndrome is associated with a group of chromosomal disorders in males in which one or more extra X chromosomes are present. The specific symptoms and the severity of Marfan syndrome vary greatly from case to case. Marfan syndrome is inherited as an autosomal dominant trait. Defects or disruptions (mutations) of the fibrillin-1. Departments and specialties. Mayo Clinic has one of the largest and most experienced practices in the United States, with campuses in Arizona, Florida and Minnesota. Staff skilled in dozens of specialties work together to ensure quality care and successful recovery

Klinefelter syndrome is a chromosomal disorder that occurs when a male is born with an additional X chromosome. Klinefelter syndrome is an uncommon genetic disorder, and it can only be diagnosed after laboratory tests are completed to determine if an individual has the disorder Klinefelter syndrome (KS) is the result of 2 or more X chromosomes in a phenotypic male. The clinical phenotype of KS was first described in males with tall stature, small testes, gynecomastia, and azoospermia, with the genetic etiology of supernumerary X chromosomes identified in 1959. Overall severity of the phenotype appears to be.

Association between the degree of mosaicism and the severity of syndrome in Turner mosaics and Klinefelter mosaics. Clin Genet 1983; 24:420. Homer L, Le Martelot MT, Morel F, et al. 45,X/46,XX mosaicism below 30% of aneuploidy: clinical implications in adult women from a reproductive medicine unit Klinefelter syndrome (KS), also known as 47,XXY, is the most frequent sex chromosome disorder, with a prevalence of 1 in 660 males. 1 Epidemiological studies demonstrate that KS is associated with. Klinefelter syndrome can raise a multitude of obstacles to optimal social, physical, and mental health development. Genetic counseling for Klinefelter is advisable as early as it is suspected or detected, in order to plan for your child or loved one's best possible maturation process and highest level of long-term well-being what is the severity of klinefelter syndrome based on -those with 46,XY/47,XXY mosaicism generally have milder phenotype -severity increases with increasing number of X chromosome

Mosaic Form Klinefelters'? - YouTubeKlinefelter syndrome (KS): genetics, clinical phenotype

What is Klinefelter Syndrome? - Living with XXY Non-Profi

  1. Klinefelter syndrome, 47, XXY is a clinical example of sex chromosome lesions. Klinefelter disease is characterized by the presence of at least one extra X chromosome in boys, which leads to impaired puberty in them. It was clinically described for the first time by Kleinfelter in 1942. The population frequency is 1: 1000 males
  2. Turner syndrome and Klinefelter syndrome are two of the most common chromosomal disorders seen in newborns. Turner syndrome occurs once in every 2,000-2,500 female births, while Klinefelter syndrome occurs once in every 500-1,000 male births.. Although there is no cure for either of these syndromes, with early diagnosis and treatment, it's possible to manage symptoms and improve quality of life
  3. The widelyvariable phenotypic spectrum and the different severity of symptoms in men with Klinefelter syndrome (KS) suggest a role for epigenetic mediators. Therefore, the aim of this study is to evaluate the possible involvement of miRNAs in the clinical manifestations of KS
Klinefelter syndrome

A Complete Guide to Klinefelter Syndrome - YourDN

• Klinefelter syndrome or Klinefelter's syndrome is the set of symptoms resulting from additional X genetic material in males. Also known as 47,XXY or XXY, Klinefelter syndrome is a genetic disorder in which there is at least one extra X chromosome to a standard human male karyotype, for a total of 47 chromosomes rather than the 46 found in. Please remember - Klinefelter's Syndrome is a spectrum condition - its effects vary enormously in both incidence and severity. Some children and adults may have few symptoms while others may be more affected. Your child is lucky to have been diagnosed early. You will be able to access support from a speech therapist or in school if needed Klinefelter syndrome and lupus. Klinefelter syndrome is a condition in which a man gets an extra X chromosome. Men usually get one X chromosome each from their mothers and one Y chromosome each from their fathers, but those with Klinefelter syndrome are XXY, which is also known as karyotype 47,XXY. 5 Klinefelter syndrome is the most common sex-chromosome disorder (47, XXY) affecting men. 1 The prevalence of KS may vary across different populations with a higher prevalence in Australia. 2 Most men with KS go through life undiagnosed, only 25% are diagnosed and only a few of these occur before puberty. Under-diagnosis of these cases is attributed to substantial variation in the clinical.

Development - Klinefelter Syndrome 101Pathology Outlines - Testicular feminization

Klinefelter syndrome - Wikipedi

  1. ation of the patient's genitals. Further tests can be requested to help.
  2. Klinefelter syndrome (KS) (47,XXY) is the most common male sex chromosome aneuploidy with a prevalence of approximately 1 in 650 males. Diagnosis of KS and prevention and treatment of its comorbidities keep being a challenge. Also the interaction pattern of the proteins encoded by the additional chromosome can influence the severity of a.
  3. If most have the variation, severity will be much greater. (3) When an individual has a particular karyotype as well as specified characteristics, their condition is defined as a syndrome. Some examples of aneuploidy associated syndromes include Trisomy 13, Trisomy 18, Down Syndrome, Turner syndrome, Klinefelter Syndrome, and XYY syndrome
  4. Nondisjunction in meiosis I or II results in gametes with abnormal chromosomal numbers and produce babies with various syndromes such as Down's syndrome (trisomy 21), Patau syndrome (trisomy 13), Edward's syndrome (trisomy 18), Klinefelter syndrome (47, XXY males), Trisomy X (47, XXX females), Monosomy X (Turner's syndrome), etc
  5. e possible neuroanatomical substrates of these cognitive and behavioral features during childhood and adolescence. METHODS. MRI brain scans were acquired for 42 XXY and 87.
  6. In 1942, Klinefelter et al. [1] published a report on 9 men who had enlarged breasts, sparse facial and body hair, small testes, and an inability to produce sperm. In 1959, these men with Klinefelter syndrome (KS) were discov-ered to have an extra X chromosome (genotype XXY) instead of the usual male sex complement (genotype XY)
  7. The severity of the symptoms depends on the number of cells with XXY pattern in the body and the level of male hormone, testosterone in the body. Physical, linguistic, and social development are three areas affected by this syndrome. Physical Growth and Development Infants with this syndrome have weaker motor skills

When only some of the person's cells have an extra X chromosome, the condition is called mosaic Klinefelter syndrome. The severity of symptoms increases with the number of cells that have an extra chromosome. There are also several variants of Klinefelter syndrome, including 48 XXYY syndrome; 48 XXXY syndrome; 49 XXXXY syndrome; and XXXY syndrome Triple X syndrome, also called trisomy X or 47,XXX, is a genetic disorder that affects about 1 in 1,000 females. Females normally have two X chromosomes in all cells — one X chromosome from each parent. In triple X syndrome, a female has three X chromosomes A few studies have examined neuropsychological functions, sleep, and mental health combined in Klinefelter syndrome (KS; 47,XXY). We investigated neuropsychological functions with standard tests, sleep with actigraphy, and self-reported mental health in 30 men with KS (Mean age = 36.7 years) compared to 21 controls (Mean age = 36.8 years) 1. Introduction. Klinefelter syndrome (XXY), or 47,XXY, is a common genetic condition caused by the presence of an extra X chromosome in males. It is estimated to occur in one in 650 males, though population-based studies in the UK and Denmark have suggested that 65-75% of individuals with XXY are undiagnosed , .While the physical and cognitive phenotype associated with XXY is highly.

The androgen insensitivity syndrome (AIS) and Klinefelter's syndrome (KS), which usually are the province of endocrinologists and geneticists, present features of importance to psychiatrists and other psychotherapists. The primary focus of this article is to attend to the psychologic features of these syndromes Try the app for free! 1. Download the 5-Minute Clinical Consult app by Unbound Medicine. 2. Select Try/Buy and follow instructions to begin your free 30-day trial. You can cancel anytime within the 30-day trial, or continue using 5-Minute Clinical Consult to begin a 1-year subscription ($39.95) Grapherence® [↑11] Klinefelter Syndrome Klinefelter syndrome 47,XXY was first described 70 years ago ().With an incidence of 0.1% to 0.2% of male neonates (i.e. 1 to 2 per 1000), it is one of the commonest congenital chromosome disorders resulting in hypogonadism and genetically-determined infertility (2, 3).Klinefelter syndrome is associated with a significantly higher morbidity rate compared to the male population as a whole Genetic analysis showed the presence of the common mutation of NEMO (exon 4-10 deletion), Klinefelter syndrome karyotype (47 XXY), and random X inactivation. This is in accordance with the severity of involvement of the affected tissues (skin, central nervous system, and retina) About 40% of concepti with Klinefelter syndrome survive in utero to the postnatal period. In general, the severity of somatic malformations in Klinefelter syndrome is proportional to the number of supernumerary X chromosomes; mental retardation and hypogonadism are more severe in patients with 49,XXXXY than in those with 48,XXXY

Phenotypic differences in mosaic Klinefelter patients as

Klinefelter Syndrome 47, XXY • Incidence 1:800 males • Neonates and infants can be asymptomatic. • Later childhood: - Delayed sexual development - Hypogenitalism, hypogonadism - Relatively long limbs - Intellectual deficiency, behavioral problems - Gynecomastia • Often detected coincidentally as is also seen in the 47, XY In general, the severity of somatic malformations in Klinefelter syndrome is proportional to the number of supernumerary X chromosomes; mental retardation and hypogonadism are more severe in. Abstract. The Klinefelter syndrome (KS), with an incidence of 1 to 2 per 1000 male neonates, is one of the most frequent congenital chromosome disorders. The 47,XXY karyotype causes infertility, testosterone deficiency and a spectrum of further symptoms and comorbidities. In recent years, significant progress has been made in the elucidation of.

Charli Darling, born a boy, developed breasts at 13 due to

Klinefelter Syndrome: Symptoms, Genetics, and Treatmen

XXY or Klinefelter's Syndrome Results February 26, 2021 | by margaretmowry Hi Mommies,I got my NIPT testing back and my baby was negative for 14 out of the 14 diseases (hooray!) but, I was informed that my baby is a male with xxy chromosomes I happen to be a transgender woman who has Kleinfelter's so hopefully I can help clear a misconception. Being transgender and having Kleinfelter's are two unrelated conditions. Someone with Kleinfelter's has the same chance of being transgender as.. In my experience no, not until I started TRT. I used to have a home gym before I was diagnosed as KS and I could never improve my bench press. It was always pathetic, maybe 25kg max. I was 6ft 3 inches and 8.5 stone. I was bullied in school for be.. Klinefelter syndrome can be caused by: One extra copy of the X chromosome in each cell (XXY), the most common cause. and greater disease severity. What is XYY syndrome? XYY syndrome is a genetic condition in which a male has an extra Y chromosome. Symptoms are usually few. They may include being taller than average, acne, and an. Klinefelter syndrome or Klinefelter's syndrome, also 47,XXY or XXY syndrome, is a genetic disorder in which there is at least one extra X chromosome to a standard human male karyotype, for a total of 47 chromosomes rather than the 46 found in genetically normal humans. While females have an XX chromosomal makeup, and males an XY, individuals with Klinefelter syndrome have at least two X.

25 Important Klinefelter Syndrome Statistics - HR

THESIS: Having Klinefelter's syndrome with the 49,XXXXY variant is a rarity in itself. I believe it occurs in 1 in every 80,000 to 100,000 births; that is only 10 to 13 for every 1,000,000 people. My brother is one of these very elite and in so many different ways very special people. II. Klinefelter's syndrome. III Klinefelter syndrome is the most common sex chromosome disorder, occurring in about 1/500 live male births. The extra X chromosomes are maternally derived in 60% of cases. Germ cells do not survive in the testes, leading to decreased sperm and androgens Objective To investigate the criminal pattern in men between 15 and 70 years of age diagnosed with 47,XXY (Klinefelter's syndrome (KS)) or 47,XYY compared to the general population. Design Register-based cohort study comparing the incidence of convictions among men with KS and with 47,XYY with age- and calendar-matched samples of the general population Klinefelter's syndrome is a genetic disorder which means that men have an XXY chromosome set up rather than the usual XY (for a male). The XXY almost always causes feminisation of men or anti-masculinisation. Klinefelter's syndrome can be extreme or non-apparent depending on the person. Usual symptoms can be : Enlarged breasts Wide hips Voice not breaking Narrow shoulders Long arms or legs. Klinefelter syndrome is a condition related to the X chromosome and Y chromosome (the sex. chromosomes). People typically have two sex chromosomes in each cell: females have two X chromosomes (46,XX), and males have one X and one Y chromosome (46,XY). f

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Describe What You're All About — The Klinefelter Syndrome

Klinefelter syndrome (47, XXY; Henceforth: XXY syndrome) is a high impact but poorly understood genetic risk factor for neuropsychiatric impairment. Here, we provide the first neuroimaging study to map resting-state functional connectivity (rsFC) changes in XXY syndrome and ask how these might relate to brain anatomy and psychopathology. We collected resting state functional magnetic resonance. How bad it is. 1 a Klinefelter syndrome patient reports severe depressed mood (5%) 12 Klinefelter syndrome patients report moderate depressed mood (60%) 5 Klinefelter syndrome patients report mild depressed mood (25%) 2 Klinefelter syndrome patients report no depressed mood (10%) What people are taking for it. Duloxetine Fluoxetine Venlafaxine Klinefelter syndrome 47,XXY was first described 70 years ago (1). With an incidence of 0.1% to 0.2% of male neonates (i.e. 1 to 2 per 1000), it is one of the commonest congenital chromosome. 1 INTRODUCTION. Turner syndrome (TS) and Klinefelter syndrome (KS) are two of the most common sex chromosome aneuploidies (Berglund et al., 2019).The prevalence of TS is approximately 1 in 2000 to 1 in 4000 among women and is characterized by a chromosomal disorder affecting phenotypically female individuals harboring one intact X chromosome and complete absence [X monosomy (45,X), resulting. Klinefelter syndrome is the most common chromosomal disorder associated with male hypogonadism and infertility. It is defined classically by a 47, XXY karyotype with variants demonstrating additional X and Y chromosomes. In general, severity of somatic malformations in Klinefelter syndrome is proportional to the number of additional X.

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Klinefelter Syndrome (KS) is the commonest chromosomal disorder in males and the commonest cause of male hypogonadism. It affects about 1 in 600 men, The severity of cognitive and psychosocial dysfunction, if present in KS individuals, is highly variable (1, 2, 3) Klinefelter syndrome (KS) is a highly prevalent sex chromosome aneuploidy syndrome that is characterized by an increased number of X chromosomes (47,XXY) in phenotypic males. Despite its frequent occurrence (up to 1 in 500 male births), clinicians often have relatively little awareness about diagnosis or management of cognitive-behavioral and. Klinefelter's Syndrome is a genetic disorder that only affects men. Those affected are born with an extra X chromosome (Belts & Frey, 2006). In 1942, Dr. Harry Klinefelter released a study concerning nine men who had little to no facial hair, enlarged breasts, small testicles, and were unable to produce sperm Most males with Klinefelter syndrome have normal intelligence levels. They can typically complete all levels of education and pursue any type of career. Between 25% and 85% of all males with Klinefelter have some kind of learning or language-related problem, though the severity can be variable. M